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In MyMemeCards, the meme card game, “Sex and Ibuprofen” is a common card of the Italian Memes pack, number 281 of the collection, and the 166th best-known meme of its 300 cards. Here is what the meme means, where it comes from, and how to get its card.
What does the “Sex and Ibuprofen” meme mean?
You use it for a night or a relationship that soothes and hurts at the same time, said in a deliberately dramatic voice. It also works as a comic shout when you want to overplay a toxic passion: you drop it on a video, an edit or a message where everything is going wrong.
Where does the “Sex and Ibuprofen” meme come from?
Aiello, an Italian singer, entered Sanremo for the first time in 2021, in the main Campioni category. He performed “Ora” on the stage of the Teatro Ariston on the evening of 2 March 2021. In the lyrics, a night spent with a former partner is summed up by the words “sesso ibuprofene”: the sex here relieves and damages at once. Italian press pieces noted that the line was already viral on social networks and had become one of the cult moments of that edition, to the point where many viewers knew it by heart.
- 2021Aiello performs “Ora” on the Ariston stage for the first time on 2 March, at the Sanremo Festival.
- 2021His album “Meridionale” is released on 12 March, days after the Festival.
How to use the “Sex and Ibuprofen” meme
- My whole weekend in one phrase: sesso e ibuprofene. Everything hurts and I regret nothing.
- She texted me at 3 a.m., I replied “sesso e ibuprofene” and the group chat got it instantly.
- I put Aiello’s chorus over the video of my cat knocking down the Christmas tree, it fits perfectly.
Also searched as
- Quella notte io e te, sesso ibuprofene
- Sesso ibuprofene
- sesso e ibuprofene meme
- Aiello Ora Sanremo 2021 meaning
- sesso e ibuprofene meaning in English
- Aiello Ora lyrics translation
- Aiello Sanremo 2021 viral line
The “Sex and Ibuprofen” card in MyMemeCards
| Number | No. 281 |
|---|---|
| Rarity | Common |
| Collection | Italian Memes pack |
| Fame | 40/100 · #166 of 300 |
| Recycle value | 5 MemeCoins (15 in Shiny) |
How to get the “Sex and Ibuprofen” card
Every pack holds 5 meme cards, the first 3 of them Common; Sex and Ibuprofen comes out of the Italian Memes pack as a common card. The pack odds say what each rarity weighs.
Your first pack is free and needs no account. After that a new free pack lands every 10 minutes, up to 3 waiting for you. You can also buy the card with MemeCoins on the market, bid for it at auction, or trade it — and a double recycles into 5 MemeCoins.
Open your free pack
5 meme cards, one of them at least Rare. One free pack per person.
Free · no account needed
Odds per card, averaged over a pack: Common 72%, Rare 23.9%, Epic 3.2%, Legendary 0.56%, Mythic 0.3%, Full Art ≤ 0.1%, Shiny 0.2%. Cards 1 to 3 are always Common, cards 4 and 5 climb the rarities. Rates drop for cards that circulate a lot. Details
Memes like “Sex and Ibuprofen”
More cards of the Italian Memes pack
Frequently asked questions
Who sings “sesso e ibuprofene”?
Aiello, in his song “Ora” performed at the Sanremo Festival 2021.
What does “sesso e ibuprofene” mean?
Literally “sex and ibuprofen”: a night that soothes and hurts at once, like an anti-inflammatory.
Which Sanremo edition did the line come from?
The 71st, in March 2021, when Aiello competed for the first time.
How do I get the Sex and Ibuprofen meme card?
Open a pack of MyMemeCards: “Sex and Ibuprofen” is a common card of the Italian Memes pack. Your first pack is free, with no account, and you can also buy, trade or win the card at auction.
How rare is the Sex and Ibuprofen card?
It is a Common card. Rarity decides which pack slot can deal it, and what it is worth on the market.
Sources: Aiello a Sanremo 2021: chi è, la canzone Ora e il sesso ibuprofene (Blitz Quotidiano) · Sanremo 2021, ecco l’esibizione di Aiello con Ora (BlogSicilia) · checked on November 5, 2026.
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Want Sex and Ibuprofen in your collection?
Open your free pack: 5 meme cards, no account needed.